Adropin and Irisin in Patients with Cardiac Cachexia

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Can Irisin be a New Agent Responsible for the Development of Heart Attack and Cardiac Cachexia?

Cardiac cachexia, a syndrome characterized by systemic destruction, nutritional impairment and weight loss [1], has a prevalence ranging between 8 and 42% around the world [2]. The syndrome was first described by the father of medicine, Hippocrates, as follows: “the flesh is consumed and becomes water; shoulders, clavicles, chest and thighs melt away. The illness is fatal” [3]. Currently the mo...

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Fat malabsorption in elderly patients with cardiac cachexia.

Malnutrition resulting from chronic congestive heart failure (cardiac cachexia, CC) is not uncommon and contributes to mortality and morbidity especially of elderly people. The aetiology of cardiac cachexia is probably multifactorial. We have assessed whether malabsorption of fat is associated with CC and if so whether it is due to small-bowel bacterial overgrowth. Three groups of subjects were...

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Irisin regulates cardiac physiology in zebrafish

Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha). We aimed to study the role of irisin on cardiac function and muscle protein regulation in zebrafish. Western blot analyses det...

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ژورنال

عنوان ژورنال: Arquivos Brasileiros de Cardiologia

سال: 2018

ISSN: 0066-782X

DOI: 10.5935/abc.20180121